Dicoumarin in Puerperal Thrombosis

Puerperal Pulmonary Thrombosis, with an Illustrative Case

Near fatal puerperal thrombosis on Björk-Shiley mitral valve prosthesis.

A 22-year-old woman required emergency mitral valve replacement three weeks post partum because of thrombotic obstruction of her prosthetic mitral valve. Low dose subcutaneous heparin was administered from the 17th week of pregnancy. Though there was a successful fetal outcome, heparin did not prevent thrombosis on the prosthesis and its continuation into the puerperium proved nearly fatal.

Estimation of Prothrombin in Dicoumarin Therapy.

The concept of prothrombin as the specific precursor of thrombin dates from the so-called classical theory of blood coagulation put forward by Schmidt (1895) and Morawitz (1905). This theory, which considers that four factors, thromboplastin, prothrombin, calcium, and fibrinogen, are concerned in the formation of fibrin, has been the basis of most modern work. The theory was of more academic th...

Alternative to oral dicoumarin anticoagulants: Considerations in dental care

INTRODUCTION For over 50 years, vitamin K antagonists such as warfarin (Aldocumar®) and acenocoumarol (Sintrom®) have been the gold standard for reducing the risk of cerebrovascular events. In the last 5 years alternative anticoagulants have been evaluated that act directly upon a concrete target within the coagulation cascade, thereby affording a more predictable anticoagulant effect. The pres...

Puerperal Septicæmia

Dr. GkddES presents the above admirable thesis based upon the fact that puerperal fever occurs more frequently in the practice of medical practitioners in Great Britain than in the practice of certified midwives, and one must confess that he has proved his case in this book. Puerperal fever, unfortunately, does not seem to get any less in its incidence, and it would appear that while the majori...